Donnerstag, September 12

9:00 - 10:00 - Ankunft & Registrierung

10:00 - 10:30 - Jörg Vogel
Begrüßung

Session 1: Antisense oligomers as alternative antibiotics
Chair: Chandradhish Ghosh

10:30 - 11:00 - Peter Nielsen
A precision antisense peptide nucleic acid antibiotics platform for fighting infections by multidrug-resistant Gram-negative bacteria

11:00 - 11:30 - Nadja Patenge
Antimicrobial Antisense Peptide Nucleic Acids for Streptococci

11:30 - 12:00 - Bruce Geller
A Brief History of the Development of Antibacterial Peptide-Phosphorodiamidate Morpholino Oligomers (PPMOs)

12:00 - 13:00 - Mittagessen

Session 2: Diverse applications of antisense technology
Chair: Linda Popella

13:00 - 13:30 - David Greenberg
Development of ASObiotics for Drug-Resistant Pseudomonas aeruginosa

13:30 - 14:00 - Eylon Yavin
Peptide Nucleic Acids (PNAs) as therapeutic and diagnostic molecules in Malaria

14:00 - 14:30 - Jörg Vogel
ASO-mediated mRNA silencing reveals essential genes in phage-host interplay

14:30 - 14:45 - Gruppenfoto & Kaffeepause

Poster Session

14:45 - 15:30 - Poster Session (gerade Zahlen)

15:30 - 16:15 - Poster Session (ungerade Zahlen)

Session 3: Approaches and challenges in ASO delivery
Chair: Kathrin Fröhlich

16:30 - 17:00 - Joanna Trylska
Delivery of antisense oligonucleotides to gram-negative bacteria via the TonB-dependent transport system

17:00 - 17:15 - Marco Galardini
A screen for ASO resistance determinants across four major pathogens

17:15 - 17:45 - Nuno F. Azevedo
Assessing the internalization and diffusion of nucleic acids in bacteria and multispecies biofilms

17:45 - 18:15 - Franziska Faber
The C. difficile cell wall - an impenetrable barrier for antisense oligomers?

19:00 - Conference Dinner - Juliusspital, Würzburg

Freitag, 13. September

Session 4: Chemical biology of peptide-based ASOs and ASO design
Chair: Claudia Höbartner

9:30 - 10:00 - Oliver Seitz
Functionalizing PNA and others for enhanced nucleic acid analysis

10:00 - 10:30 - Hans Michael Maric
PNA synthesis for CATwalking essential bacterial genes

10:30 - 11:00 - Lars Barquist
A data science approach to defining design rules for ASO antibiotics

11:00 - 11:15 - Kaffeepause

11:15 - 12:15 - Podiumsdiskussion

12:15 - 12:30 - Schlussbemerkungen

12:30 - Mittagessen und Verabschiedung