Prof. Chase Beisel
Über
Seit seiner Doktorarbeit 2009 im Fach Chemieingenieurwesen am California Institute of Technology (Pasadena, USA) befasst sich Chase Beisel mit Fragen des RNA-Engineering. Nach zwei Jahren an den National Institutes of Health (Bethesda, Maryland, USA) begann er 2011 seine Fakultätstätigkeit in der Abteilung für chemische und biomolekulare Verfahrenstechnik an der North Carolina State University (Raleigh, North Carolina, USA), wo er sich mit RNA-gesteuerten Immunsystemen, so genannten CRISPR-Cas-Systemen, beschäftigte und zum Associate Professor (Tenure) befördert wurde. Seit 2018 forscht er am HIRI im Bereich RNA-Engineering, mit dem Ziel, Infektionskrankheiten besser zu verstehen, zu diagnostizieren und zu behandeln.
2025
Purification and in vivo, cell-free, and in vitro characterization of CRISPR-Cas12a2
Schut FT, Hallmark T, Dmytrenko O, Jackson RN, Beisel CL (2025)
Methods In Enzymology (Online ahead of print)DOI: 10.1016/bs.mie.2025.01.032
AcrVIB1 inhibits CRISPR-Cas13b immunity by promoting unproductive crRNA binding accessible to RNase attack
Wandera KG, Schmelz S, Migur A, Kibe A, Lukat P, Achmedov T, Caliskan N, Blankenfeldt W, Beisel CL (2025)
Molecular Cell (Online ahead of print)DOI: 10.1016/j.molcel.2025.01.020
2024
A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection
Jabalera Y, Tascón I, Samperio S, López-Alonso JP, Gonzalez-Lopez M, Aransay AM, Abascal-Palacios G, Beisel CL, Ubarretxena-Belandia I, Perez-Jimenez R (2024)
Nature Biotechnology (Online ahead of print)DOI: 10.1038/s41587-024-02461-3
Phages to the rescue: in situ editing of the gut microbiota
Kamm C, Beisel CL (2024)
Trends in Microbiology 32 (10): 934-935DOI: 10.1016/j.tim.2024.09.001
Ten Years of the Synthetic Biology Summer Course at Cold Spring Harbor Laboratory
Haynes KA, Andrews LB, Beisel CL, Chappell J, Cuba Samaniego CE, Dueber JE, Dunlop MJ, Franco E, Lucks JB, Noireaux V, …, Smanski M, Young E (2024)
ACS Synthetic Biology 13 (9): 2635-2642DOI: 10.1021/acssynbio.4c00276
MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation
Arias-Rojas A, Arifah AQ, Angelidou G, Alshaar B, Schombel U, Forest E, Frahm D, Brinkmann V, Paczia N, Beisel CL, Gisch N, Iatsenko I (2024)
PLOS Pathogens 20 (8): e1012462DOI: 10.1371/journal.ppat.1012462
Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein
Birkholz N, Kamata K, Feussner M, Wilkinson ME, Cuba Samaniego C, Migur A, Kimanius D, Ceelen M, Went SC, Usher B, …, Jackson SA, Fineran PC (2024)
Nature 631 (8021): 670-677DOI: 10.1038/s41586-024-07644-1
TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases
Jiao C, Peeck NL, Yu J, Ghaem Maghami M, Kono S, Collias D, Martinez Diaz SL, Larose R, Beisel CL (2024)
Nature Communications 15 (1): 5909DOI: 10.1038/s41467-024-50243-x
A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria
Vento JM, Durmusoglu D, Li T, Patinios C, Sullivan S, Ttofali F, van Schaik J, Yu Y, Wang Y, Barquist L, Crook N, Beisel CL (2024)
Molecular Cell 84 (14): 2785-2796.e4DOI: 10.1016/j.molcel.2024.06.003
Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans
Benz F, Camara-Wilpert S, Russel J, Wandera KG, Cepaite R, Ares-Arroyo M, Gomes-Filho JV, Englert F, Kuehn JA, Gloor S, …, Sørensen SJ, Pinilla-Redondo R (2024)
Cell Host & Microbe 32 (6): 875-886.e9DOI: 10.1016/j.chom.2024.04.016
Expanding the flexibility of base editing for high-throughput genetic screens in bacteria
Gawlitt S, Collins SP, Yu Y, Blackman SA, Barquist L, Beisel CL (2024)
Nucleic Acids Research 52 (7): 4079-4097DOI: 10.1093/nar/gkae174
CRISPR-based screening of small RNA modulators of bile susceptibility in Bacteroides thetaiotaomicron
Prezza G, Liao C, Reichardt S, Beisel CL, Westermann AJ (2024)
Proceedings of the National Academy of Sciences of the United States of America 121 (6): 1096DOI: 10.1073/pnas.2311323121
A Hitchhiker's guide to CRISPR editing tools in bacteria : CRISPR can help unlock the bacterial world, but technical and regulatory barriers persist
Krink N, Nikel PI, Beisel CL (2024)
EMBO Reports 25 (4): 1694-1699DOI: 10.1038/s44319-024-00086-w
An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between Klebsiella species
Almási ÉdH, Knischewski N, Osbelt L, Muthukumarasamy U, El Mouali Y, Vialetto E, Beisel CL, Strowig T (2024)
Journal of Bacteriology 206 (3): e0031723DOI: 10.1128/jb.00317-23
Improved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect machine learning and data integration
Yu Y, Gawlitt S, de Andrade E Sousa LB, Merdivan E, Piraud M, Beisel CL, Barquist L (2024)
Genome Biology 25 (1): 13DOI: 10.1186/s13059-023-03153-y