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Prof. Chase Beisel

Über

Seit seiner Doktorarbeit 2009 im Fach Chemieingenieurwesen am California Institute of Technology (Pasadena, USA) befasst sich Chase Beisel mit Fragen des RNA-Engineering. Nach zwei Jahren an den National Institutes of Health (Bethesda, Maryland, USA) begann er 2011 seine Fakultätstätigkeit in der Abteilung für chemische und biomolekulare Verfahrenstechnik an der North Carolina State University (Raleigh, North Carolina, USA), wo er sich mit RNA-gesteuerten Immunsystemen, so genannten CRISPR-Cas-Systemen, beschäftigte und zum Associate Professor (Tenure) befördert wurde. Seit 2018 forscht er am HIRI im Bereich RNA-Engineering, mit dem Ziel, Infektionskrankheiten besser zu verstehen, zu diagnostizieren und zu behandeln. 

2024

A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection

Jabalera Y, Tascón I, Samperio S, López-Alonso JP, Gonzalez-Lopez M, Aransay AM, Abascal-Palacios G, Beisel CL, Ubarretxena-Belandia I, Perez-Jimenez R (2024)

Nature Biotechnology (Online ahead of print)DOI: 10.1038/s41587-024-02461-3

Phages to the rescue: in situ editing of the gut microbiota

Kamm C, Beisel CL (2024)

Trends in Microbiology 32 (10): 934-935DOI: 10.1016/j.tim.2024.09.001

Ten Years of the Synthetic Biology Summer Course at Cold Spring Harbor Laboratory

Haynes KA, Andrews LB, Beisel CL, Chappell J, Cuba Samaniego CE, Dueber JE, Dunlop MJ, Franco E, Lucks JB, Noireaux V, …, Smanski M, Young E (2024)

ACS Synthetic Biology 13 (9): 2635-2642DOI: 10.1021/acssynbio.4c00276

MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation

Arias-Rojas A, Arifah AQ, Angelidou G, Alshaar B, Schombel U, Forest E, Frahm D, Brinkmann V, Paczia N, Beisel CL, Gisch N, Iatsenko I (2024)

PLOS Pathogens 20 (8): e1012462DOI: 10.1371/journal.ppat.1012462

Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein

Birkholz N, Kamata K, Feussner M, Wilkinson ME, Cuba Samaniego C, Migur A, Kimanius D, Ceelen M, Went SC, Usher B, …, Jackson SA, Fineran PC (2024)

Nature 631 (8021): 670-677DOI: 10.1038/s41586-024-07644-1

TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases

Jiao C, Peeck NL, Yu J, Ghaem Maghami M, Kono S, Collias D, Martinez Diaz SL, Larose R, Beisel CL (2024)

Nature Communications 15 (1): 5909DOI: 10.1038/s41467-024-50243-x

A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria

Vento JM, Durmusoglu D, Li T, Patinios C, Sullivan S, Ttofali F, van Schaik J, Yu Y, Wang Y, Barquist L, Crook N, Beisel CL (2024)

Molecular Cell 84 (14): 2785-2796.e4DOI: 10.1016/j.molcel.2024.06.003

Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans

Benz F, Camara-Wilpert S, Russel J, Wandera KG, Cepaite R, Ares-Arroyo M, Gomes-Filho JV, Englert F, Kuehn JA, Gloor S, …, Sørensen SJ, Pinilla-Redondo R (2024)

Cell Host & Microbe 32 (6): 875-886.e9DOI: 10.1016/j.chom.2024.04.016

Expanding the flexibility of base editing for high-throughput genetic screens in bacteria

Gawlitt S, Collins SP, Yu Y, Blackman SA, Barquist L, Beisel CL (2024)

Nucleic Acids Research 52 (7): 4079-4097DOI: 10.1093/nar/gkae174

CRISPR-based screening of small RNA modulators of bile susceptibility in Bacteroides thetaiotaomicron

Prezza G, Liao C, Reichardt S, Beisel CL, Westermann AJ (2024)

Proceedings of the National Academy of Sciences of the United States of America 121 (6): 1096DOI: 10.1073/pnas.2311323121

A Hitchhiker's guide to CRISPR editing tools in bacteria : CRISPR can help unlock the bacterial world, but technical and regulatory barriers persist

Krink N, Nikel PI, Beisel CL (2024)

EMBO Reports 25 (4): 1694-1699DOI: 10.1038/s44319-024-00086-w

An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between Klebsiella species

Almási ÉdH, Knischewski N, Osbelt L, Muthukumarasamy U, El Mouali Y, Vialetto E, Beisel CL, Strowig T (2024)

Journal of Bacteriology 206 (3): e0031723DOI: 10.1128/jb.00317-23

Improved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect machine learning and data integration

Yu Y, Gawlitt S, de Andrade E Sousa LB, Merdivan E, Piraud M, Beisel CL, Barquist L (2024)

Genome Biology 25 (1): 13DOI: 10.1186/s13059-023-03153-y

2023

Interrogating two extensively self-targeting Type I CRISPR-Cas systems in Xanthomonas albilineans reveals distinct anti-CRISPR proteins that block DNA degradation

Wimmer F, Englert F, Wandera KG, Alkhnbashi OS, Collins SP, Backofen R, Beisel CL (2023)

Nucleic Acids Research 52 (2): 769-783DOI: 10.1093/nar/gkad1097

Shortened CRISPR-Cas9 arrays enable multiplexed gene targeting in bacteria from a smaller DNA footprint

Gawlitt S, Liao C, Achmedov T, Beisel CL (2023)

RNA Biology 20 (1): 666-680DOI: 10.1080/15476286.2023.2247247

For the CRISPR Fan(zor)atics: RNA-guided DNA endonucleases discovered in eukaryotes

Patinios C, Beisel CL (2023)

Molecular Cell 83 (17): 3046-3048DOI: 10.1016/j.molcel.2023.08.019

A predicted CRISPR-mediated symbiosis between uncultivated archaea

Esser SP, Rahlff J, Zhao W, Predl M, Plewka J, Sures K, Wimmer F, Lee J, Adam PS, McGonigle J, …, Zhang Y, Probst AJ (2023)

Nature Microbiology 8 (9): 1619-1633DOI: 10.1038/s41564-023-01439-2

Optimized metrics for orthogonal combinatorial CRISPR screens

Cetin R, Wegner M, Luwisch L, Saud S, Achmedov T, Süsser S, Vera-Guapi A, Müller K, Matthess Y, Quandt E, …, Beisel CL, Kaulich M (2023)

Scientific Reports 13 (1): 7405DOI: 10.1038/s41598-023-34597-8

Systematically attenuating DNA targeting enables CRISPR-driven editing in bacteria

Collias D, Vialetto E, Yu J, Co K, Almási ÉDH, Rüttiger AS, Achmedov T, Strowig T, Beisel CL (2023)

Nature Communications 14 (1): 680DOI: 10.1038/s41467-023-36283-9

RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2

Bravo JPK, Hallmark T, Naegle B, Beisel CL, Jackson RN, Taylor DW (2023)

Nature 613 (7944): 582-587DOI: 10.1038/s41586-022-05560-w

Cas12a2 elicits abortive infection through RNA-triggered destruction of dsDNA

Dmytrenko O, Neumann GC, Hallmark T, Keiser DJ, Crowley VM, Vialetto E, Mougiakos I, Wandera KG, Domgaard H, Weber J, …, Jackson RN, Beisel CL (2023)

Nature 613 (7944): 588-594DOI: 10.1038/s41586-022-05559-3

RNA recording in single bacterial cells using reprogrammed tracrRNAs

Jiao C, Reckstadt C, König F, Homberger C, Yu J, Vogel J, Westermann AJ, Sharma CM, Beisel CL (2023)

Nature Biotechnology 41 (8): 1107-1116DOI: 10.1038/s41587-022-01604-8