Prof Franziska Faber
About
Franziska Faber studied biology at the Martin-Luther University (Halle/Saale, Germany). Her doctoral work at the Robert Koch Institute (Wernigerode, Germany) introduced her to the field of enteric bacterial infections. In 2011, she started her postdoctoral work in the lab of Andreas Bäumler at the University of California (Davis, USA). Here, she studied the mechanisms by which antibiotic treatment lowers “colonization resistance” against the enteric pathogen Salmonella enterica. More specifically, she explored how inflammation-associated changes in intestinal nutrients contribute to intestinal colonization of S. enterica. In 2018, she joined the Center for Infectious Disease Research (ZINF) in Würzburg as a Young Investigator to study the previously unexplored RNA biology of the intestinal pathogen Clostridioides difficile. Since 2021, she has been a Junior Professor at the Institute of Molecular Infection Biology (IMIB) and has since headed the ROSE group at Julius-Maximilians-Universität (JMU) Würzburg, which is associated with the HIRI. In 2023, she was appointed to a W2 professorship at the Institute for Hygiene and Microbiology at JMU.
2024
Formation of the pyruvoyl-dependent proline reductase Prd from Clostridioides difficile requires the maturation enzyme PrdH
Behlendorf C, Diwo M, Neumann-Schaal M, Fuchs M, Körner D, Jänsch L, Faber F, Blankenfeldt W (2024)
PNAS nexus 3 (7): pgae249DOI: 10.1093/pnasnexus/pgae249
2023
Durchfallerreger und die Homöostase der Mikrobiota
Winter S, Faber F, Bäumler A (2023)
BIOspektrum 29 (2): 127-129DOI: 10.1007/s12268-023-1901-3
A network of small RNAs regulates sporulation initiation in C difficile
Fuchs M, Lamm-Schmidt V, Lence T, Sulzer J, Bublitz A, Wackenreuter J, Gerovac M, Strowig T, Faber F (2023)
EMBO Journal 42 (12): e112858DOI: 10.15252/embj.2022112858
2021
Grad-seq identifies KhpB as a global RNA-binding protein in Clostridioides difficile that regulates toxin production
Lamm-Schmidt V, Fuchs M, Sulzer J, Gerovac M, Hör J, Dersch P, Vogel J, Faber F (2021)
microLife 2: uqab004DOI: 10.1093/femsml/uqab004
Malaria parasite infection compromises colonization resistance to an enteric pathogen by reducing gastric acidity
Walker GT, Yang G, Tsai JY, Rodriguez JL, English BC, Faber F, Souvannaseng L, Butler BP, Tsolis RM (2021)
Science Advances 7 (27): eabd6232DOI: 10.1126/sciadv.abd6232
The metabolic footprint of Clostridia and Erysipelotrichia reveals their role in depleting sugar alcohols in the cecum
Tiffany CR, Lee JY, Rogers AWL, Olsan EE, Morales P, Faber F, Bäumler AJ (2021)
Microbiome 9 (1): 174DOI: 10.1186/s40168-021-01123-9
An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important gram-positive bacterium
Fuchs M, Lamm-Schmidt V, Sulzer J, Ponath F, Jenniches L, Kirk JA, Fagan RP, Barquist L, Vogel J, Faber F (2021)
PNAS 118 (25): e2103579118DOI: 10.1073/pnas.2103579118
RNA landscape of the emerging cancer-associated microbe Fusobacterium nucleatum
Ponath F, Tawk C, Zhu Y, Barquist L, Faber F, Vogel J (2021)
Nature Microbiology 6 (8): 1007-1020DOI: 10.1038/s41564-021-00927-7
2020
Antibacterial Anacardic Acid Derivatives
Saedtler M, Förtig N, Ohlsen K, Faber F, Masota N, Kowalick K, Holzgrabe U, Meinel L (2020)
ACS Infectious Diseases 6 (7): 1674-1685DOI: 10.1021/acsinfecdis.9b00378
2019
Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition
Litvak Y, Mon KKZ, Nguyen H, Chanthavixay G, Liou M, Velazquez EM, Kutter L, Alcantara MA, Byndloss MX, Tiffany CR, …, Zhou H, Bäumler AJ (2019)
Cell Host & Microbe 25 (1): 128-139.e5DOI: 10.1016/j.chom.2018.12.003
Social behaviour and making attachments: a report from the fifth 'Young Microbiologists Symposium on Microbe Signalling, Organisation and Pathogenesis'
An SQ, Ding YC, Faber F, Hobley L, Sá-Pessoa J (2019)
Microbiology 165 (2): 138-145DOI: 10.1099/mic.0.000746
Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection
Velazquez EM, Nguyen H, Heasley KT, Saechao CH, Gil LM, Rogers AWL, Miller BM, Rolston MR, Lopez CA, Litvak Y, …, Byndloss AJ, Bäumler AJ (2019)
Nature Microbiology 4 (6): 1057-1064DOI: 10.1038/s41564-019-0407-8
2018
Genetic Ablation of Butyrate Utilization Attenuates Gastrointestinal Salmonella Disease
Bronner DN, Faber F, Olsan EE, Byndloss MX, Sayed NA, Xu G, Yoo W, Kim D, Ryu S, Lebrilla CB, Bäumler AJ (2018)
Cell Host & Microbe 23 (2): 266-273.e4DOI: 10.1016/j.chom.2018.01.004
2017
Colonization resistance: The deconvolution of a complex trait
Olsan EE, Byndloss MX, Faber F, Rivera-Chávez F, Tsolis RM, Bäumler AJ (2017)
The Journal of Biological Chemistry 292 (21): 8577-8581DOI: 10.1074/jbc.R116.752295
A Salmonella Regulator Modulates Intestinal Colonization and Use of Phosphonoacetic Acid
Elfenbein JR, Knodler LA, Schaeffer AR, Faber F, Bäumler AJ, Andrews-Polymenis HL (2017)
Frontiers in Cellular and Infection Microbiology 7: 69DOI: 10.3389/fcimb.2017.00069
Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis
Faber F, Thiennimitr P, Spiga L, Byndloss MX, Litvak Y, Lawhon S, Andrews-Polymenis HL, Winter SE, Bäumler AJ (2017)
PLOS Pathogens 13 (1): e1006129DOI: 10.1371/journal.ppat.1006129
Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion
Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, …, Lebrilla CB, Bäumler AJ (2017)
Science 357 (6351): 570-575DOI: 10.1126/science.aam9949
2016
Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella
Rivera-Chávez F, Zhang LF, Faber F, Lopez CA, Byndloss MX, Olsan EE, Xu G, Velazquez EM, Lebrilla CB, Winter SE, Bäumler AJ (2016)
Cell Host & Microbe 19 (4): 443-54DOI: 10.1016/j.chom.2016.03.004
Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion
Faber F, Tran L, Byndloss MX, Lopez CA, Velazquez EM, Kerrinnes T, Nuccio SP, Wangdi T, Fiehn O, Tsolis RM, Bäumler AJ (2016)
Nature 534 (7609): 697-9DOI: 10.1038/nature18597
2015
Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection
Mooney JP, Lokken KL, Byndloss MX, George MD, Velazquez EM, Faber F, Butler BP, Walker GT, Ali MM, Potts R, …, Luckhart S, Tsolis RM (2015)
Scientific Reports 5: 14603DOI: 10.1038/srep14603
2014
The impact of intestinal inflammation on the nutritional environment of the gut microbiota
Faber F, Bäumler AJ (2014)
Immunology Letters 162 (2 Pt A): 48-53DOI: 10.1016/j.imlet.2014.04.014
Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation
Winter SE, Winter MG, Poon V, Keestra AM, Sterzenbach T, Faber F, Costa LF, Cassou F, Costa EA, Alves GE, …, Santos RL, Bäumler AJ (2014)
PLOS Pathogens 10 (7): e1004207DOI: 10.1371/journal.ppat.1004207
2012
Surface-associated motility, a common trait of clinical isolates of Acinetobacter baumannii, depends on 1,3-diaminopropane
Skiebe E, de Berardinis V, Morczinek P, Kerrinnes T, Faber F, Lepka D, Hammer B, Zimmermann O, Ziesing S, Wichelhaus TA, …, Pfeifer Y, Wilharm G (2012)
International Journal of Medical Microbiology 302 (3): 117-28DOI: 10.1016/j.ijmm.2012.03.003
2010
A simple and rapid method of bacterial transformation
Wilharm G, Lepka D, Faber F, Hofmann J, Kerrinnes T, Skiebe E (2010)
Journal of Microbiological Methods 80 (2): 215-6DOI: 10.1016/j.mimet.2009.12.002
Orbus hercynius gen. nov., sp. nov., isolated from faeces of wild boar, is most closely related to members of the orders 'Enterobacteriales' and Pasteurellales
Volkmann M, Skiebe E, Kerrinnes T, Faber F, Lepka D, Pfeifer Y, Holland G, Bannert N, Wilharm G (2010)
International Journal of Systematic and Evolutionary Microbiology 60 (Pt 11): 2601-2605DOI: 10.1099/ijs.0.019026-0
2009
CsrA and CsrB are required for the post-transcriptional control of the virulence-associated effector protein AvrA of Salmonella enterica
Kerrinnes T, Zelas ZB, Streckel W, Faber F, Tietze E, Tschäpe H, Yaron S (2009)
International Journal of Medical Microbiology 299 (5): 333-41DOI: 10.1016/j.ijmm.2008.09.001
2007
Influence of poly(L-lysine) on the structure of dipalmitoylphosphatidylglycerol/water dispersions studied by X-ray scattering
Förster G, Schwieger C, Faber F, Weber T, Blume A (2007)
European Biophysics Journal 36 (4-5): 425-35DOI: 10.1007/s00249-006-0087-1
2006
Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice
Faber F, Gembardt F, Sun X, Mizutani S, Siems WE, Walther T (2006)
Regulatory Peptides 136 (1-3): 130-7DOI: 10.1016/j.regpep.2006.06.001