Prof Antoine-Emmanuel Saliba
About
Antoine-Emmanuel Saliba studied biochemical engineering at INSA Toulouse (France) and received his PhD in the research group of Jean-Louis Viovy at the Institut Curie (Paris, France). During this time, he developed microfluid-based systems for sorting and analysing rare subpopulations of cancer cells. He then worked as an EIPOD fellow at the European Molecular Biology Laboratory (Heidelberg, Germany) and was involved in the development of innovative systems biology methods for the analysis of protein-lipid interactions. He then joined Jörg Vogel's laboratory in Würzburg as a senior postdoctoral fellow and established single-cell RNA-sequencing to track the fate of individual cells during an infection with Salmonella enterica. Since 2017, he has led the Single-cell Analysis group at HIRI. As of 2023, he also holds a professorship (W2) at the Faculty of Medicine of the University of Würzburg.
2024
Alternating high-fat diet enhances atherosclerosis by neutrophil reprogramming
Lavillegrand JR, Al-Rifai R, Thietart S, Guyon T, Vandestienne M, Cohen R, Duval V, Zhong X, Yen D, Ozturk M, …, Riksen NP, Ait-Oufella H (2024)
Nature 634 (8033): 447-456DOI: 10.1038/s41586-024-07693-6
A novel in vitro tubular model to recapitulate features of distal airways: The bronchioid
Maurat E, Raasch K, Leipold AM, Henrot P, Zysman M, Prevel R, Trian T, Krammer T, Bergeron V, Thumerel M, …, Recher G, Dupin I (2024)
The European Respiratory journal 64 (4)DOI: 10.1183/13993003.00562-2024
Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human disease
Friedrich VD, Pennitz P, Wyler E, Adler JM, Postmus D, Müller K, Teixeira Alves LG, Prigann J, Pott F, Vladimirova D, …, Kirsten H, Nouailles G (2024)
EBioMedicine 108: 105312DOI: 10.1016/j.ebiom.2024.105312
Characterization and implementation of the MarathonRT template-switching reaction to expand the capabilities of RNA-Seq
Guo LT, Grinko A, Olson S, Leipold A, Graveley B, Saliba AE, Pyle AM (2024)
RNA 30 (11): 1495–1512DOI: 10.1261/rna.080032.124
The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation
Knoll R, Helbig ET, Dahm K, Bolaji O, Hamm F, Dietrich O, van Uelft M, Müller S, Bonaguro L, Schulte-Schrepping J, …, Aschenbrenner AC, Kurth F (2024)
Cell 187 (16): 4318-4335.e20DOI: 10.1016/j.cell.2024.06.014
L-Wnk1 Deletion in Smooth Muscle Cells Causes Aortitis and Inflammatory Shift
Quelquejay H, Al-Rifai R, Silvestro M, Vandestienne M, Ferreira I, Mirault T, Henrion D, Zhong X, Santos-Zas I, Goudot G, …, Jeunemaitre X, Ait-Oufella H (2024)
Circulation Research 135 (4): 488-502DOI: 10.1161/CIRCRESAHA.124.324366
CD8+ T Cells Drive Plaque Smooth Muscle Cell Dedifferentiation in Experimental Atherosclerosis
Schäfer S, Gogiraju R, Rösch M, Kerstan Y, Beck L, Garbisch J, Saliba AE, Gisterå A, Hermanns HM, Boon L, …, Cochain C, Zernecke A (2024)
Arteriosclerosis Thrombosis, and Vascular biology 44 (8): 1852-1872DOI: 10.1161/ATVBAHA.123.320084
Characterization of a Human Respiratory Mucosa Model to Study Odorant Metabolism
Mérignac-Lacombe J, Kornbausch N, Sivarajan R, Boichot V, Berg K, Oberwinkler H, Saliba AE, Loos HM, Ehret Kasemo T, Scherzad A, …, Heydel JM, Steinke M (2024)
Journal of Agricultural and Food Chemistry 72 (22): 12696-12706DOI: 10.1021/acs.jafc.4c00752
TREM2 protects from atherosclerosis by limiting necrotic core formation
Piollet M, Porsch F, Rizzo G, Kapser F, Schulz DJ, Kiss MG, Schlepckow K, Morenas-Rodriguez E, Sen MO, Gropper J, …, Binder CJ, Cochain C (2024)
Nature Cardiovascular Research 3 (3): 269-282DOI: 10.1038/s44161-024-00429-9
Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis
Kumar N, Prakash PG, Wentland C, Kurian SM, Jethva G, Brinkmann V, Mollenkopf HJ, Krammer T, Toussaint C, Saliba AE, …, Gurumurthy RK, Chumduri C (2024)
Nature Communications 15 (1): 3064DOI: 10.1038/s41467-024-47173-z
Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells
Costa B, Becker J, Krammer T, Mulenge F, Durán V, Pavlou A, Gern OL, Chu X, Li Y, Cicin-Šain L, …, Erhard F, Kalinke U (2024)
Nature Communications 15 (1): 1745DOI: 10.1038/s41467-024-45614-3
Sequential Antigen-loss and Branching Evolution in Lymphoma after CD19- and CD20-Targeted T-cell Redirecting Therapy
Duell J, Leipold AM, Appenzeller S, Fuhr V, Rauert-Wunderlich H, Da Vià MC, Dietrich O, Toussaint C, Imdahl F, Eisele F, …, Saliba AE, Rasche L (2024)
Blood 143 (8): 685-696DOI: 10.1182/blood.2023021672
2023
Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson's disease
McFleder RL, Makhotkina A, Groh J, Keber U, Imdahl F, Peña Mosca J, Peteranderl A, Wu J, Tabuchi S, Hoffmann J, …, Volkmann J, Ip CW (2023)
Nature Communications 14 (1): 7529DOI: 10.1038/s41467-023-43224-z
Vector-borne Trypanosoma brucei parasites develop in artificial human skin and persist as skin tissue forms
Reuter C, Hauf L, Imdahl F, Sen R, Vafadarnejad E, Fey P, Finger T, Jones NG, Walles H, Barquist L, …, Groeber-Becker F, Engstler M (2023)
Nature Communications 14 (1): 7660DOI: 10.1038/s41467-023-43437-2
Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects
Groh J, Abdelwahab T, Kattimani Y, Hörner M, Loserth S, Gudi V, Adalbert R, Imdahl F, Saliba AE, Coleman M, …, Simons M, Martini R (2023)
Nature Communications 14 (1): 6911DOI: 10.1038/s41467-023-42570-2
Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy
Zhang Y, Vandestienne M, Lavillegrand JR, Joffre J, Santos-Zas I, Lavelle A, Zhong X, Le Goff W, Guérin M, Al-Rifai R, …, Sokol H, Ait-Oufella H (2023)
Nature Communications 14 (1): 4622DOI: 10.1038/s41467-023-40216-x
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Eyraud E, Maurat E, Sac-Epée JM, Henrot P, Zysman M, Esteves P, Trian T, Dupuy JW, Leipold A, Saliba AE, …, Berger P, Dupin I (2023)
eLife 12: RP85875DOI: 10.7554/eLife.85875
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks
Ugur M, Labios RJ, Fenton C, Knöpper K, Jobin K, Imdahl F, Golda G, Hoh K, Grafen A, Kaisho T, …, Bajénoff M, Kastenmüller W (2023)
Immunity 58 (8): 1778-1793.e10DOI: 10.1016/j.immuni.2023.06.020
Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed oligodendrocytes in PLP1 mutant mice
Abdelwahab T, Stadler D, Knöpper K, Arampatzi P, Saliba AE, Kastenmüller W, Martini R, Groh J (2023)
iScience 26 (5): 106698DOI: 10.1016/j.isci.2023.106698
An interferon gamma response signature links myocardial aging and immunosenescence
Ashour D, Rebs S, Arampatzi P, Saliba AE, Dudek J, Schulz R, Hofmann U, Frantz S, Cochain C, Streckfuß-Bömeke K, Ramos GC (2023)
Cardiovascular Research 119 (14): 2458-2468DOI: 10.1093/cvr/cvad068
Advancing massive transcriptional profiling of single bacteria
Saliba AE (2023)
Cell Reports Methods 3 (2): 100416DOI: 10.1016/j.crmeth.2023.100416
A primary cell-based in vitro model of the human small intestine reveals host olfactomedin 4 induction in response to Salmonella Typhimurium infection
Däullary T, Imdahl F, Dietrich O, Hepp L, Krammer T, Fey C, Neuhaus W, Metzger M, Vogel J, Westermann AJ, Saliba AE, Zdzieblo D (2023)
Gut Microbes 15 (1): 2186109DOI: 10.1080/19490976.2023.2186109
Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma
Leipold AM, Werner RA, Düll J, Jung P, John M, Stanojkovska E, Zhou X, Hornburger H, Ruckdeschel A, Dietrich O, …, Saliba AE, Rasche L (2023)
Leukemia 37 (3): 650-658DOI: 10.1038/s41375-023-01824-0
Myocardial Milieu Favors Local Differentiation of Regulatory T Cells
Delgobo M, Weiß E, ElDin Ashour D, Richter L, Popiolkowski L, Arampatzi P, Stangl V, Arias-Loza P, Mariotti-Ferrandiz E, Rainer PP, …, Frantz S, Campos Ramos G (2023)
Circulation Research 132 (5): 565-582DOI: 10.1161/CIRCRESAHA.122.322183
Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19
Zhang B, Zhang Z, Koeken VACM, Kumar S, Aillaud M, Tsay HC, Liu Z, Kraft ARM, Soon CF, Odak I, …, Schulte LN, Li Y (2023)
Cell Genomics 3 (2): 100232DOI: 10.1016/j.xgen.2022.100232
A MATQ-seq-Based Protocol for Single-Cell RNA-seq in Bacteria
Homberger C, Saliba AE, Vogel J (2023)
Methods in Molecular Biology 2584: 105-121DOI: 10.1007/978-1-0716-2756-3_4
Integrated single-cell analysis based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis
Zernecke A, Erhard F, Weinberger T, Schulz C, Ley K, Saliba AE, Cochain C (2023)
Cardiovascular Research 119 (8): 1676-1689DOI: 10.1093/cvr/cvac161
Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction
Rizzo G, Gropper J, Piollet M, Vafadarnejad E, Rizakou A, Bandi SR, Arampatzi P, Krammer T, DiFabion N, Dietrich O, …, Saliba AE, Cochain C (2023)
Cardiovascular Research 119 (3): 772-785DOI: 10.1093/cvr/cvac113
Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles
Akbar N, Braithwaite AT, Corr EM, Koelwyn GJ, van Solingen C, Cochain C, Saliba AE, Corbin A, Pezzolla D, Møller Jørgensen M, …, Melling GE, Shanmuganathan M (2023)
Cardiovascular Research 119 (1): 236-251DOI: 10.1093/cvr/cvac012